Kinetic resolution of indolines through reductive amination of aldehydes by chiral Brønsted acid

Yingwei Wang,Guangxun Li,Hongxin Liu,Zhuo Tang,Yuan Cao,Gang Zhao

Tetrahedron Letters（2017）

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摘要

•The method provided a concise methodology for the synthesis of chiral indolines.•An external hydride transfer agent was used for the KR of racemic indolines.•The reaction was good complementary to Akiyama’s work.

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关键词

Kinetic resolution,Indolines,Chiral Brønsted acid,Hydride donor,Transfer hydrogenation

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