Significantly mutated genes and regulatory pathways in SCLC—a meta-analysis

Varsha Sundaresan,Victor T. Lin,Faming Liang,Frederic J. Kaye,Reika Kawabata-Iwakawa,Kouya Shiraishi,Takashi Kohno,Jun Yokota,Lei Zhou

Cancer Genetics（2017）

引用 15|浏览34

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摘要

•Genes with low mutation frequencies were identified as highly significant in SCLC.•Axon guidance pathway genes are likely to play an important role in SCLC.•Mutation rate is higher in samples with RB1 mutation compared to those with wild type RB1.

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关键词

Small cell lung cancer,high-throughput sequencing data,meta-analysis,significantly mutated genes,PTEN,RB1

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