Chromatographic profiling of Pancharishta at different stages of its development using HPTLC, HPLC, GC–MS and UPLC–MS

•Stepwise preparation of an important Ayurvedic Pancharishta formulation as per traditional claims.•Quality control evaluation of different Pancharishta formulations by HPTLC and quantitative differentiation by HPLC.•Metabolic discrimination of different Pancharishta formulation through UPLC–MS and GC–MS.•Describing the statistical correlation among different Pancharishta formulation.