Creating A National Collaborative Strategy To Enhance Trial Accrual In Nci'S National Clinical Trials Network (Nctn) In The Era Of Precision Medicine

6589 Background: NCI launched the NCTN on March 1, 2014 to reinvigorate the publically funded cancer trials system. As precision medicine (PM) trials increasingly require screening large numbers of patients to identify a subset of patients whose tumors contain specific molecular targets, national accrual strategies are needed. We report findings from a Network-wide interactive meeting held in Dec, 2014 to explore accrual to PM and adolescent and young adult (AYA) trials. Methods: NCI convened a 2-day meeting of NCTN grantees and NCI staff, with 75 representatives from Groups, Patient Advocates u0026 Lead Academic Participating Sites (LAPS), to discuss accrual in the era of PM. Accrual challenges and strategies were identified via a mixed method approach: pre-meeting worksheets, trial case studies, group and breakout sessions and a priority ranking activity. Findings were triangulated to determine next steps to maximize future accrual. Results: Key themes identified included the need to streamline trial commun...