Differential Impact Of Cisplatin Dose Intensity On Human Papillomavirus (Hpv)-Related (+) And Hpv-Unrelated (-) Locoregionally Advanced Head And Neck Squamous Cell Carcinoma (Lahnscc).

6020 Background: Definitive radiotherapy with concurrent cisplatin (CDDP) is a standard treatment for patients (pts) with LAHNSCC. We evaluated the impact of CDDP dose intensity (mg/m2) on overall survival (OS) of HPV+ and HPV- LAHNSCC pts. Methods: Princess Margaret Cancer Centre (PM) and Istituto Nazionale dei Tumori (INT) LAHNSCC cohorts treated from 2000 to 2012 were reviewed. Kaplan-Meier method was used to estimate the 5-year (yr) OS in HPV+ vs HPV− pts. HPV status was determined by p16 staining or in situ hybridization HPV DNA for all oropharyngeal (OPC), unknown primary (UNK), and ≤ 10 pack-year (PY) smoking laryngo-hypopharyngeal cancer (LHC). Untested p16, u003e10 PY LHC pts were assumed HPV−. Multivariable analysis (MVA) with Cox regression identified OS predictors for HPV+ and HPV− pts. Results: A total of 659 pts (584 PM; 75 INT) were evaluated. Pts characteristics included: median age 58 (range: 27-81); primary site: OPC 73%, LHC 24%, UNK 3%; non-smokers 27%; stage: T4 25%, N2c-N3 60%; HPV+ 404 ...