Focal Hifu (High Intensity Focused Ultrasound) Treatment Of Unilateral Localized Prostate Cancer: Hemiablation Strategy-A Prospective French Multicentric Study With 111 Patients.

102 Background: Up to a third of patients with localized prostate cancer (LPCa) have unilateral disease that may be suitable for a treatment of one lobe. Our aim was to evaluate the ability of HIFU to achieve a local control of the tumor in patients with unilateral LPCa. Methods: The French Urological Association (AFU) conducted a multi-institutional study, to evaluate hemi-ablation with HIFU as a primary treatment for patients u003e50 years, T1C or T2A, PSAu003c10ng/ml, Gleason ≤7 (3+4), and unilateral disease. 111 patients were treated: mean age 64.8 ±6.18 years, mean PSA 6.23±2.5 ng/ml. Gleason sum was ≤6 in 73.9% and 7 in 26.1%.primary outcome was the negative biopsy rate. Secondary outcomes were genitourinary side effects measured using validated questionnaires. The tumor was localized using MRI followed by random and targeted transrectal biopsies. Only the pathological prostate lobe was treated using HIFU. Results: The PSA nadir value was 1.87±1.49 ng/ml and the PSA at 12 months was 2.49±2.1 ng/ml (median 1...