Radioimmunotherapy with I131 Tositumomab in Relapsed and Transformed Low-Grade (LG) Non-Hodgkin's Lymphoma (NHL): Long-Term Follow-Up of a Single Institution Experience.

Background: Tositumomab and Iodine I 131 Tositumomab (BEXXAR®) is approved for the treatment of recurrent LG or transformed CD20+ NHL refractory to Rituximab or relapsed after chemotherapy. In 5 trials and an expanded access program (>995 pts), response rates were 47%–68% (durable CRs in up to 30%) with median response durations of 12–18 months. Most pts who relapsed post-BEXXAR tolerated subsequent cytotoxic regimens, stem cell transplant, localized radiation, Rituximab, and Bexxar re-treatment.