卵圆孔未闭与先兆性偏头痛的关系及其可能机制研究进展 The Relationship and Possible Mechanism between Patent Foramen Ovale and Migraine with Aura

卵圆孔未闭(Patent foramen ovale, PFO)在正常人中的发生率大约为1/4，近年来越来越多的数据表明卵圆孔未闭与脑卒中、偏头痛等临床疾病相关。而目前一些研究发现卵圆孔未闭与先兆性偏头痛(Migraine with aura, MA)之间的关系更为密切，主要认为是一些化学物质通过未闭的卵圆孔进入脑部循环而诱发偏头痛。由于偏头痛对患者的身心健康造成严重影响和损害，降低了患者的生活质量和工作效率，并且给家庭和社会带来严重的经济负担，因而深入了解偏头痛的发生机制对于预防和治疗偏头痛起着至关重要的作用。本文通过对卵圆孔未闭与先兆性偏头痛的可能关系及其可能机制进行阐述，为临床中预防和治疗先兆性偏头痛患者提供更充分的理论依据。 The incidence of patent foramen ovalen is 1/4 among normal people; more and more data show that patent foramen ovale is correlated with stroke, migraine and other clinical disease in recent years. At present, some studies have found that patent foramen ovale is closely related with migraine with aura, mainly considered that some chemicals went into the brain circulation by the open way of patent foramen ovale which induced migraine attack. Due to the serious damage of physical and mental health of the migraine, bad quality of life and work productivity, and serious economic burden to families and society, exploring the mechanism of migraine to better treat the disease is meaningful. In this paper, through explaining the relationship and its possible mechanism between patent foramen ovale and migraine with aura, the aim is to provide more adequate theories for better clinical prevention and treatment of patients of the migraine with aura.