OX40: Structure and function – What questions remain?

Jane Willoughby, Jordana Griffiths,Ivo Tews,Mark S. Cragg

Molecular Immunology（2017）

引用 101|浏览31

暂无评分

摘要

•The OX40:OX40L interaction is a key regulator of T cell responses.•OX40L is part of divergent class of TNF superfamily ligands.•OX40 signalling can promote Teffector proliferation as well as inhibit Treg function.•Potential immunotherapeutic target for cancer, inflammatory and autoimmune diseases.•Further understanding of context dependent function will improve clinical outcomes.

查看译文

关键词

ADCC,APCs,Ag,CDC,CRD,CTL,DP,Fc,FcγR,GVHD,h,iTreg,KO,LTa,m,mAb,MHC,NK,NKT,nTreg,PDB,SP,TCR,Tg,TLRs,TNFRSF,TNFSF,TRAF,Tregs,TSLP,WT

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要