Clinical and biological effects of demethylating agents on solid tumours – A systematic review
Cancer Treatment Reviews(2017)
摘要
•Changes in methylation play a key role in tumour development and therapy resistance.•Demethylating agents are beneficial for a subset of patients with solid tumours.•Decrease in methylation is of limited use to predict clinical response.•Alternative effects e.g. activation of the immune system, are potentially promising.
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关键词
Epigenetics,Solid tumour,Demethylating agents,DNMT inhibitor,Therapy resistance,Immune response
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