Processing of ketoconazole–4-aminobenzoic acid cocrystals using dense CO2 as an antisolvent

Gunaree Kotbantao,Manop Charoenchaitrakool

Journal of CO2 Utilization（2017）

引用 27|浏览3

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摘要

•KET–PABA cocrystals were successfully produced by GAS.•Drug content in cocrystals produced by GAS was 77%, equivalent to 1:1 molar ratio.•KET in the cocrystals obtained from GAS could dissolve 47.5±5.9% after 4h.•KET–PABA cocrystal could dissolve 2.6 times faster than the unprocessed KET.

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关键词

Crystallization,Cocrystal,Ketoconazole,4-amino benzoic acid,Gas

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