P109 High Affinity Engagement of the αvβ6 Integrin Induces Degradation: A Novel Mechanism for Sustained Inhibition of Pro-Fibrotic TGFβ Activation.
QJM: An International Journal of Medicine（2016）
摘要
The arginyl-glycinyl-aspartic acid (RGD) integrin alpha-v beta-6 (αvβ6) has been identified as playing a key role in the activation of transforming growth factor-β (TGFβ) that is hypothesised to be pivotal in the development of fibrosis. In this study αvβ6 …
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