Regio‐ and Stereoselective Preparation of β,γ‐Unsaturated Carboxylic Acids by One‐Pot Sequential Double 1,6‐Addition of Grignard Reagents to Methyl Coumalate
Advanced Synthesis and Catalysis(2016)
摘要
An efficient regio‐ and stereoselective metal‐catalyzed addition of two Grignard reagents (homo‐coupling, 2 RMgX or hetero‐coupling, R1MgX+R2MgX) to methyl coumalate (methyl 2‐oxo‐2H‐pyran‐5‐carboxylate) is described. This synthetic approach opens the access to a wide variety of functionalized β,γ‐unsaturated carboxylic acids in a modular way. Control of the chemo‐ and stereoselectivity of this one‐pot procedure is discussed.
更多查看译文
关键词
double 1,6-conjugate addition,6-π electrocyclic ring opening,Grignard reagents,metal catalysis,unsaturated acids
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要