Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines as potential anticancer agents

Stereo- and regio-selective synthesis of 3′-C-substituted-(N)-methanocarba adenosines 3a–c as potential anticancer agents was achieved by employing stereoselective cyclopropanation, stereoselective nucleophilic addition, regioselective isopropylidene cleavage and regioselective base condensation of cyclic sulfate as key steps.