Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial

Deborah J. Cook,Jennie Johnstone,John C. Marshall,Francois Lauzier,Lehana Thabane,Sangeeta Mehta,Peter M. Dodek,Lauralyn McIntyre, Joe Pagliarello,William Henderson,Robert W. Taylor,Rodrigo Cartin-Ceba,Eyal Golan,Margaret Herridge,Gordon Wood,Daniel Ovakim,Tim Karachi,Michael G. Surette,Dawn M. E. Bowdish,Daphnee Lamarche,Chris P. Verschoor,Erick H. Duan,Diane Heels-Ansdell,Yaseen Arabi,Maureen Meade, For the PROSPECT Investigators and the Canadian Critical Care Trials Group

Trials（2016）

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摘要

Probiotics are live microorganisms that may confer health benefits when ingested. Randomized trials suggest that probiotics significantly decrease the incidence of ventilator-associated pneumonia (VAP) and the overall incidence of infection in critically ill patients. However, these studies are small, largely single-center, and at risk of bias. The aim of the PROSPECT pilot trial was to determine the feasibility of conducting a larger trial of probiotics to prevent VAP in mechanically ventilated patients in the intensive care unit (ICU).

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关键词

Critically ill,Infection,Intensive care,Probiotics

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