A highly sensitive LC–MS/MS method for determination of ketoconazole in human plasma: Application to a clinical study of the exposure to ketoconazole in patients after topical administration

Keli Wang,Yao Wu,Zhiyan Chi,Chang Shu,Lingjun Li,Jun Wei,Lei Tao,Pengcheng Ma,Li Ding

Journal of Pharmaceutical and Biomedical Analysis（2016）

引用 9|浏览5

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摘要

•First clinical study of ketoconazole foam in Chinese seborrheic dermatitis patients.•Simple sample preparation procedure and short analytical run time.•The LLOQ of ketoconazole was 0.01ng/mL.

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关键词

LLOQ,IS,QC,LQC,MQC,HQC,MRM,RE,RSD

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