Development of a high-throughput β-Gal-based neutralization assay for quantitation of herpes simplex virus-neutralizing antibodies in human samples.

Amy Baccari, Michael Cooney,Tamara P. Blevins,Lynda A. Morrison,Shane Larson,Mojca Skoberne,Robert B. Belshe,Jessica B. Flechtner,Deborah Long

Vaccine（2016）

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摘要

•Development of a high-throughput, low variability colorimetric HSV-neutralization assay.•Strong inter-laboratory correlation of titers using different β-Gal-based assays.•Tool for measuring HSV-1 or HSV-2 NAb titers in infected and/or vaccine immunized individuals.

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关键词

Herpes simplex virus,Neutralization,Antibody titer,Assay

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