Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin

Reham Atteya,Mohamed E. Ashour,Elsayed E. Ibrahim,Mohamed A. Farag,Sherif F. El-Khamisy

Mechanisms of Ageing and Development（2017）

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摘要

•Synergistic cytotoxicity of harmine and doxorubicin on MCF-7 breast cancer cells.•Harmine does not enhance the cytotoxicity of Etoposide or Camptothecin.•Doxorubicin and harmine combination could reduce doxorubicin’s cardiotoxicity.

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关键词

Doxorubicin,TOP2,Harmine,Cardiotoxicity,Natural products,DYRK1A kinase

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