Function of the residues Met~(76) and Gln~(79) in HLA--G alpha1 domain in KIR2DL4 recognition

Chinese journal of microbiology and immunology, pp. 875-878, 2006.

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Abstract:

Objective To investigate the biological function of the unique residues Met~(76)and Gln~(79)in HLA-Gα1 domain in HLA-G specific receptor KIR2DL4 recognition.Methods Eukaryotic vector CD51neg1 was applied to generate the soluble fusion protein IR2DL4-IgG Fc.The codons encoding Met~(76)and Gln~(79)were mutated to Ala~(76,79)in HLA-Gα1 domai...More

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