2,2,2-Trifluoroethanol activated one-pot Mannich-like reaction of β-nitroenamines, secondary amines, and aromatic aldehydes

Li Han,Yian Feng,Ming Luo,Zihao Yuan,Xusheng Shao,Xiaoyong Xu,Zhong Li

Tetrahedron Letters（2016）

引用 13|浏览4

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摘要

•A unique and efficient one-pot reaction of β-nitroenamines, secondary amines, and aromatic aldehydes.•2,2,2-Trifluoroethanol (TFEA) was used to activate this reaction.•Afford the desired Mannich-like products in moderate to excellent yields with wide substrate scopes.

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关键词

2,2,2-Trifluoroethanol,β-Nitroenamines,Mannich-like reaction,One-pot reaction

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