A Massé Shot: Transition-Metal-Catalyzed Selective meta-C–H Functionalization (ortho-Metallation and para-Bromination Relay)

Reviewed herein are a number of modern approaches for the meta-selective direct C-H functionalization of substituted arenes, including a recent discovery on Ru-catalyzed meta-bromination is also discussed with the mechanistically interesting features (ortho-metallation and para-functionalization relay). 1 Introduction 2 Transition-Metal-Mediated meta-C-H Activation 3 Ruthenium-Catalyzed meta-C-H Bromination 4 Conclusion and Future Directions