Effect of Primary Letrozole Treatment on Tumor Expression of mTOR and HIF-1α and Relation to Clinical Response.

Daniele Generali,Alfredo Berruti,Maria Rosa Cappelletti,Laura Zanotti,Giulia Brugnoli,Michela Forti,Francesca Bedussi, Maria Elena Vailati,Manuela Milani,Carla Strina,Mara Ardine,Sergio Aguggini,Giovanni Allevi,Giuseppina Ferrero,Ramona Bertoni,Alberto Bottini,Adrian L. Harris,Stephen B. Fox

Journal of the National Cancer Institute. Monographs（2015）

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摘要

In this neoadjuvant population, LET was able to modulate the phospho-mTOR and HIF-1α pathways and may define a subpopulation of nonresponders who may be most likely to benefit from mTOR inhibitors.

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