High glucose regulates LN expression in human liver sinusoidal endothelial cells through ROS/integrin αvβ3 pathway

Jing Liu,Jinxing Quan,Jing Feng,Qi Zhang,Yanjia Xu,Jia Liu,Wenhui Huang,Juxiang Liu,Limin Tian

Environmental Toxicology and Pharmacology（2016）

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摘要

•High glucose can elicit the production of ROS, integrin αvβ3 and LN in HLSECs.•High glucose-induced up-regulation of integrin αvβ3 in HLSECs was mediated by ROS.•High glucose-induced high expression of LN in HLSECs was mediated by integrin αvβ3 receptor.

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关键词

HLSECs,High glucose,Integrin αvβ3,Laminin,ROS

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