Effect of Butyric Acid on p53 Expression and Apoptosis in Colon Epithelial Cells in Mice after Treated with 9,10-dimethyl-1,2-benz(a)anthracene☆

As the most common cancer, colorectal cancer is the fourth leading cause of death among this malignancy disease. Surgery procedure with chemotherapy and radiotherapy for colorectal cancer treatment may cause unpleasant side effects. Therefore, prevention and early detection of the disease is important. Butyrate, a short chain fatty acid, has a protective effect against colon cancer by inhibiting cell proliferation and inducing apoptosis. We conduct a research to investigate the effect of butyrate as a possible agent to decreased mutant p53 gene expression.