Underlying mechanisms of recombinant adeno-associated virus-mediated bicaudal C homolog 1 overexpression in the medial prefrontal cortex of mice with induced depressive-like behaviors.

Zhengchun Wang,Dongsheng Zhou,Shuting Li,Yanhua Zhang,Chuang Wang

Brain Research Bulletin（2019）

引用 7|浏览3

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摘要

•Overexpression of BICC1 in the mPFC-induced the depression-like phenotype in mice.•Overexpression of BICC1 changed the Dvl2/GSK3β/mTOR signaling in mice.•Overexpression of BICC1 downregulated the GluA1 trafficking.

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关键词

Bicaudal C homolog 1 gene (BICC1),Depression,GSK3β,mTOR,GluA1

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