GATA2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in humans.

Journal of Allergy and Clinical Immunology（2019）

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摘要

GATA2 deficient patients have a low prevalence of allergic disease resulting from impaired IgE-mediated mast cell activation; thus, GATA2 represents a novel therapeutic target for clinical allergy.

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关键词

FcεRI,GATA2,IgE,KIT,SCF,allergy,mast cell activation

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