Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study

    Vaccine, Volume 37, Issue 26, 2019, Pages 3485-3494.

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    Keywords:
    Controlled human infectionGroup A StreptococcusHuman challengeHuman infection studiesStreptococcus pyogenesMore(1+)

    Abstract:

    Group A Streptococcus (GAS) is a highly-adapted and human-restricted pathogen responsible for a high global burden of disease across a diverse clinical spectrum. Vaccine development has been impeded by scientific, regulatory, and commercial obstacles. Human infection studies (HIS) are increasingly contributing to drug, diagnostics, and va...More

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