Effects of continuous high-dose G-CSF administration on hematopoietic stem cell mobilization and telomere length in patients with amyotrophic lateral sclerosis - a pilot study.

Sabine Iberl,Anne-Louise Meyer,Gunnar Müller,Sebastian Peters,Siw Johannesen,Ines Kobor,Fabian Beier,Tim H Brümmendorf,Christina Hart,Roland Schelker,Wolfgang Herr,Ulrich Bogdahn,Jochen Grassinger

Cytokine（2019）

引用 6|浏览24

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摘要

•We monitored six ALS patients up to 3.5 years.•Continuous high-dose G-CSF administration was safe.•Despite intense G-CSF treatment mobilization of CD34+ HSPC was not enhanced.•Long-term G-CSF application did not shorten telomeres in ALS patients’ leukocytes.•Serum cytokines revealed G-CSF-mediated immunomodulatory and proteolytic effects.

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关键词

Amyotrophic lateral sclerosis, ALS,Granulocyte-colony stimulating factor, G-CSF,Hematopoietic stem and progenitor cells, HSPC,Telomere length,Cytokines

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