MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24.

Fei Han,Qishan Chen, Jia Su,Ancheng Zheng,Kai Chen,Shasha Sun,Hong Wu,Liujun Jiang,Xiaolei Xu,Mei Yang,Feng Yang,Jianhua Zhu,Li Zhang

Journal of Molecular and Cellular Cardiology（2019）

引用 39|浏览28

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摘要

Our findings strongly demonstrated that miR-124 targeting Dhcr24 regulates oxidative stress and hypoxia induced cardiomyocyte apoptosis and myocardial infarction. The miR-124-Dhcr24 axis could be a potential biomarker as well as the therapeutic target for AMI.

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