Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

    Janine Lu
    Janine Lu
    Alexander Underwood
    Alexander Underwood
    Rodrigo Velázquez-Moctezuma
    Rodrigo Velázquez-Moctezuma
    Johnathan D Guest
    Johnathan D Guest

    PLoS pathogens, Volume 15, Issue 5, 2019.

    Cited by: 0|Bibtex|Views5|Links
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    Abstract:

    Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral clearance during acute hepatitis C virus (HCV) infection. Information on the timing and specificity of the B cell response associated with clearance is crucial to inform vaccine design. From an individual who cleared three sequential HCV infe...More

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