The Role of Double-balloon Enteroscopy in Reducing the Maximum Size of Polyps in Patients with Peutz-Jeghers Syndrome: 12-Year Experience.

Objective This study aimed to evaluate the role of double-balloon enteroscopy (DBE) in treating intestinal polyps in patients with Peutz-Jeghers syndrome (PJS). Methods All patients diagnosed with PJS who underwent a polypectomy under DBE from October 2006 to December 2018 were enrolled. Their clinical records, including surgical history, the method of DBE insertion, the number of DBE procedures, and the maximum size and number of the resected polyps, were retrospectively reviewed. Results Altogether 97 patients were enrolled. For both antegrade and retrograde DBE the maximum size of the resected polyps during the second hospitalization was significantly smaller than that during the first hospitalization (antegrade DBE: [2.13 +/- 1.51] cm vs [3.63 +/- 0.92] cm, P = 0.012; retrograde DBE: [1.20 +/- 1.10] cm vs [2.95 +/- 1.95] cm, P = 0.03), but was significantly larger than that during the third hospitalization (antegrade DBE: [2.13 +/- 1.51] cm vs [0.88 +/- 0.70] cm, P = 0.012; retrograde DBE: [1.20 +/- 1.10] cm vs [0.46 +/- 0.40] cm, P = 0.048). The interval between the second and third hospitalizations was significantly longer than that between the first and second hospitalizations ([899.00 +/- 382.12] days vs [537.27 +/- 326.28] days, P = 0.027). The success rate of total enteroscopy was 58.3% (28/48), which was not affected by a history of laparotomy (61.5% vs 52.4%, P = 0.528). The complication rate was 4.4%. Conclusion DBE is clinically safe and effective for the diagnosis and treatment of intestinal polyps in patients with PJS.