MiR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability.
Biomedicine & Pharmacotherapy(2019)
摘要
•MiR-4319 acts as a tumor suppressor in NSCLC progression.•MiR-4319 leads to the destabilization of RFX5 by targeting LIN28.•RFX5 motivates the transcription of YAP.•MiR-4319 dampened YAP expression to mitigate the tumorigenesis of NSCLC.
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关键词
miR-4319,YAP,LIN28,RFX5,NSCLC
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