Fused Hexacyclic Ring System Through Interrupted iso-Nazarov Initiated Diastereoselective Domino Polycyclization of 2,4-Dienals.

We report an unprecedented domino polycyclization from readily available 2,4-dienals and cyclic a, b-unsaturated imines that is initiated by an iso-Nazarov reaction. This Bronsted acid promoted reaction enables the concomitant formation of four bonds, three cycles, and four contiguous stereogenic centers to yield elaborated structures in a single operation. A range of fused hexacyclic molecules is obtained in a highly diastereoselective manner.