Over-Expression of PTEN Suppresses the Proliferation and Migration of Fibroblast-Like Synoviocytes in Adjuvant-Induced Arthritis.

Xiao-Feng Li,Biao Song,Qing-Qin Xu,Su-Qin Yin,Xin Chen,Le Xu,Lei Zhang,Jia-Gen Wen,Cheng Huang,Xiao-Ming Meng,Jun Li

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2019）

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摘要

Our findings suggest that PTEN might play a pivotal role in the proliferation and migration of FLSs through the activation of the AKT signaling pathway. Additionally, PTEN expression may be regulated by DNA methylation in the pathogenesis of AIA.

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关键词

Adjuvant-induced arthritis,DNA methylation,Migration,PTEN,Proliferation

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