Accelerated immunodeficiency-associated vaccine derived poliovirus serotype 3 (iVDPV3) sequence evolution rate in a 3-month old boy with X-linked agammaglobulinemia and perinatal HIV exposure.

Sabelle Jallow,Jo M Wilmshurst,Wayne Howard, Julie Copelyn,Lerato Seakamela,Koon-Wing Chan,Robert Sebunya, Rosinah Sibiya,Heleen Du Plessis, Charlene Jacobs, Natacha Berkowitz,Lucille Blumberg,Kerrigan McCarthy,Elizabeth Maseti,Mercy Kamupira, Nonhlanhla Dlamini,Nicksy Gumede,Ousmane M Diop,Yu Lung Lau,Shelina Moonsamy,Brian Eley,Melinda Suchard

CLINICAL INFECTIOUS DISEASES（2020）

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摘要

Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.

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关键词

oral poliovirus vaccine,acute flaccid paralysis,X-linked agammaglobulinemia,Bruton tyrosine kinase,HIV-exposed but uninfected

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