Copy number variation-based gene set analysis reveals cytokine signalling pathways associated with psychiatric comorbidity in patients with inflammatory bowel disease.

•CNV analysis was performed in a cohort of 243 IBD sample with Caucasian ethnicity;•Medium-sized CNV burden is significantly higher in IBD patients with psychiatric comorbidity (PC) than those without PC;•Cytokine signalling pathways by deletions-overlapped genes are significantly overrepresented in the IBD patients with PC.