BDNF and NT3 Reprogram Human Ectomesenchymal Dental Pulp Stem Cells to Neurogenic and Gliogenic Neural Crest Progenitors Cultured in Serum-Free Medium.

Jon Luzuriaga,Jose Ramon Pineda,Igor Irastorza,Veronica Uribe-Etxebarria,Patricia García-Gallastegui,Juan Manuel Encinas,Pablo Chamero,Fernando Unda,Gaskon Ibarretxe

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2019）

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摘要

Our results demonstrate that the use of BDNF and NT-3 combined with STP induced the partial reprogramming of ectomesenchymal hDPSCs to generate early NC progenitor cells, which are far more competent for neuronal and glial differentiation than hDPSCs grown in the presence of FBS.

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关键词

Brain Derived Neurotrophic Factor,Calcium imaging,Cell differentiation,Dental Pulp Stem Cells,Serum-free culture media

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