Virology: Poxins Soothe the STING.
Current Biology（2019）
摘要
The mammalian cyclic dinucleotide 2',3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham et al. identified poxins as 2',3'-cGAMP-specific nucleases allowing immune evasion by viruses.
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