Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

    Rodrigo Velázquez-Moctezuma
    Rodrigo Velázquez-Moctezuma
    Elias H Augestad
    Elias H Augestad

    Proceedings of the National Academy of Sciences of the United States of America, 2019, Pages 201822002

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    Keywords:
    N-linked glycansenvelope breathingenvelope protein 2hepatitis C virusneutralizing antibodies

    Abstract:

    About two million new cases of hepatitis C virus (HCV) infections annually underscore the urgent need for a vaccine. However, this effort has proven challenging because HCV evades neutralizing antibodies (NAbs) through molecular features of viral envelope glycoprotein E2, including hypervariable region 1 (HVR1) and N-linked glycans. Here,...More

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