Non-invasive diagnosis of early-stage lung cancer using high-throughput targeted DNA methylation sequencing of circulating tumor DNA (ctDNA)

    Yue Zhao
    Yue Zhao
    Yangbin Gao
    Yangbin Gao
    Weihong Xu
    Weihong Xu
    Jinsheng Tao
    Jinsheng Tao
    Meng Yang
    Meng Yang
    Lequn Li
    Lequn Li
    Zhiwei Chen
    Zhiwei Chen

    Theranostics, Volume 9, Issue 7, 2019, Pages 2056-2070.

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    Keywords:
    Early-stage lung cancercirculating tumor DNAhigh-throughput targeted DNA methylation sequencing

    Abstract:

    LDCT screening can identify early-stage lung cancers yet introduces excessive false positives and it remains a great challenge to differentiate malignant tumors from benign solitary pulmonary nodules, which calls for better non-invasive diagnostic tools. We performed DNA methylation profiling by high throughput DNA bisulfite sequencing ...More

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