New Cadinane Sesquiterpenes from the Stems of .
MOLECULES(2019)
摘要
As part of our continual efforts to exploit Tujia Ethnomedicine' for their pharmacophoric functionalities, we herein investigated Kadsura heteroclita collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6,9,15-trihydroxycadinan-4-en-3-one (1), (+)-3,11,12-trihydroxycalamenene (2), (-)-3,10,11,12-tetrahydroxy-calamenene (3), along with four known sesquiterpenes (4-7), and a cytochalasin H (8). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound 8 exhibited a strong antioxidant effect with an IC50 value of 3.67 mu M on isolated human polymorphonuclear cells or neutrophils.
更多查看译文
关键词
Kadsura heteroclita,Schisandraceae,sesquiterpenes,antioxidant,Tujia ethnomedicine
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络