The AmyI-1-18 peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production induced by lipopolysaccharide and interleukin-1β in mice.

The AmyI-1-18 peptide from rice inhibited alveolar bone destruction in mouse periodontitis model via suppressing inflammatory cytokine production induced by LPS. It was suggested AmyI-1-18 peptide has anti-inflammatory property against LPS, not only by neutralization of LPS and subsequent inhibition of nuclear factor (NF)-κB signaling but also by inhibition of the IL-1R-related signaling cascade. This article is protected by copyright. All rights reserved.