Effect of teduglutide on restoring oral autonomy for magnesium in two patients with short bowel.

•Patients with short bowel show clinical instability with secretion of magnesium from their stoma making intravenous (IV) magnesium the only safe treatment.•Teduglutide is a glucagonlike peptide that proliferates microvilli and enhances calorie and hydration absorption.•Previously, it was not known whether teduglutide was able to break IV magnesium dependency.•This is the first report to track increasing magnesium in two patients on teduglutide and to determine that management was safe without IV.•The increase in magnesium occurred at the time that onset of action of the drug was observed in other studies.