Triple A patient cells suffering from mitotic defects fail to localize PGRMC1 to mitotic kinetochore fibers.

Ramona Jühlen,Dana Landgraf,Angela Huebner,Katrin Koehler

Cell division（2018）

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摘要

Our results emphasize the possibility that loss of the regulatory association between ALADIN and PGRMC2 gives rise to a depletion of PGRMC1 at kinetochore fibers. This observation may explain part of the symptoms seen in triple A syndrome patients.

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关键词

ALADIN,Kinetochore fibers,Mitosis,Nuclear pore complex,PGRMC1,PGRMC2,Triple A syndrome

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