Adjuvant haploidentical virus-specific T lymphocytes for treatment of disseminated adenovirus infection in a premature infant.

Jeffery J Auletta,Pablo J Sánchez,Erin K Meyer,Lynn C O'Donnell,Kevin A Cassady,Christopher P Ouellette,Shaina Hecht,Alejandro Diaz,Leeann R Pavlek,Douglas P Salamon,Christina L Gallagher, Hillary Bradbury, Sarah L Welfley,Jacqueline Magers, Debra L Armbruster,Margaret G Lamb,Robin J Nakkula, Kevin Bosse,Dean A Lee

The Journal of allergy and clinical immunology（2019）

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摘要

We report the first therapeutic infusion of haploidentical virus-specific T lymphocytes (VSTs) to treat maternally-transmitted, disseminated adenovirus infection in a premature infant. Infusion of maternal VSTs, isolated using interferon-gamma capture, associated with clinical improvement and viral clearance.

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