Role of Arf-like proteins (Arl1 and Arl2) of Mucor circinelloides in virulence and antifungal susceptibility.

Fungal Genetics and Biology(2019)

引用 17|浏览10
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摘要
•Two Arf-like proteins are encoded in the genome of M. circinelloides.•Arl1 and Arl2 share 55% sequence identity with different expression profiles.•Arl1 is essential for M. circinelloides growth.•Arl1 and Arl2 dysfunction led to mislocalization of vesicles in the hyphae.•Arl1 is important for sporulation, virulence, and resistance to antifungal agents.
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关键词
ADP-ribosylation factor,Arl proteins,Antifungal,Mucor circinelloides,Vesicle trafficking,Virulence
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