Gα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling.

Min Chen,Eric A Wilson,Zhenzhong Cui,Hui Sun,Yogendra B Shrestha,Brandon Podyma, Christina H Le,Benedetta Naglieri,Karel Pacak,Oksana Gavrilova,Lee S Weinstein

Molecular Metabolism（2019）

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摘要

•Gsα deficiency in the dorsomedial hypothalamus (DMH) leads to severe obesity associated with hyperphagia.•Loss of Gsα in DMH reduces energy expenditure, locomotion and thermogenesis.•Loss of MC4R in DMH reduces energy expenditure but not locomotion or thermogenesis.•Loss of Gsα impairs leptin signaling in DMH.

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关键词

G protein,Obesity,Thermogenesis,Hypothalamus,Sympathetic nervous system

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