Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation.

Manuela Mura,Yee-Ki Lee,Federica Pisano,Monia Ginevrino,Marina Boni,Federica Calabrò,Lia Crotti,Enza Maria Valente,Peter J Schwartz,Hung-Fat Tse,Massimiliano Gnecchi

Stem cell research（2019）

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摘要

We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a woman carrier of the heterozygous mutation c.568C > T p.R190W on the KCNQ1 gene. hiPSCs, obtained using four retroviruses enconding the reprogramming factors OCT4, SOX2, cMYC and KLF4, display pluripotent stem cell characteristics, and can be differentiated into spontaneously beating cardiomyocytes (hiPSC-CMs).

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