Right ventricular pressure overload alters cardiac lipid composition

A.M.C. Koop,Q.A.J. Hagdorn, G.P.L. Bossers, T. van Leusden, A. Gerding,M. van Weeghel, F.M. Vaz,D.P.Y. Koonen, H.H.W. Silljé, R.M.F. Berger,B. Bartelds

International Journal of Cardiology（2019）

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摘要

•Right ventricular (RV) pressure load induces early RV dysfunction.•Altered lipid composition accompanies RV dysfunction.•Lipid decreases in RV pressure load are driven by poly-unsaturated fatty acids.•Decrease of cardiolipins and diglycerides precede mitochondrial dysfunction.•RV dysfunction is associated with early upregulation of oxidative stress markers.

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关键词

Right ventricular dysfunction,Hypertrophy,Metabolism,Diglyceride,Cardiolipin

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