Dopamine receptor D (DRD) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

P M Butler,W Chiong,D C Perry,Z A Miller,E D Gennatas,J A Brown,L Pasquini,A Karydas, D Dokuru,G Coppola,V E Sturm,A L Boxer, M L Gorno-Tempini,H J Rosen,J H Kramer,B L Miller,W W Seeley

NeuroImage: Clinical（2019）

引用 3|浏览40

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摘要

•Common variants of the DRD4 gene worsen neurodegeneration in FTD.•DRD4 dampened-variants aggravate atrophy in anterior brain structures in FTD.•Behavioral apathy in FTD is associated with DRD4 polymorphisms and related atrophy.•Salience network sites exhibit vulnerability to injury due to DRD4 genotype in FTD.•Polymorphisms predict atrophy in the insula in bvFTD and anterior cingulate in svPPA.

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关键词

Frontotemporal dementia,DRD4,Apathy,Insula,Anterior cingulate cortex,Salience network

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